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Alexandre Barbosa Reis Selected Research

Visceral Leishmaniasis (Kala Azar)

1/2022Comparative evaluation of meglumine antimoniate encapsulated in a mixture of conventional and PEGylated liposomes and immunotherapy using an anti-canine IL-10 receptor-blocking monoclonal antibody on canine visceral leishmaniasis.
1/2022Immunochemotherapy for visceral leishmaniasis: combinatorial action of Miltefosine plus LBSapMPL vaccine improves adaptative Th1 immune response with control of splenic parasitism in experimental hamster model.
12/2021A chimeric vaccine combined with adjuvant system induces immunogenicity and protection against visceral leishmaniasis in BALB/c mice.
7/2021Repositioning of Tamoxifen in Surface-Modified Nanocapsules as a Promising Oral Treatment for Visceral Leishmaniasis.
1/2021Heterologous vaccine therapy associated with half course of Miltefosine promote activation of the proinflammatory response with control of splenic parasitism in a hamster model of visceral leishmaniasis.
1/2021IL-10 receptor blockade controls the in vitro infectivity of Leishmania infantum and promotes a Th1 activation in PBMC of dogs with visceral leishmaniasis.
11/2020Phase I and II Clinical Trial Comparing the LBSap, Leishmune®, and Leish-Tec® Vaccines against Canine Visceral Leishmaniasis.
5/2020Chimeric Vaccines Designed by Immunoinformatics-Activated Polyfunctional and Memory T Cells That Trigger Protection against Experimental Visceral Leishmaniasis.
1/2020Laboratorial algorithm for serological diagnosis of visceral leishmaniasis using rK39-ICT, DAT-LPC and FC-Simplex IgG1.
10/2019Synthetic Peptides Elicit Strong Cellular Immunity in Visceral Leishmaniasis Natural Reservoir and Contribute to Long-Lasting Polyfunctional T-Cells in BALB/c Mice.
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Alexandre Barbosa Reis Research Topics

Disease

48Visceral Leishmaniasis (Kala Azar)
01/2022 - 06/2004
23Infections
01/2021 - 09/2005
12Leishmaniasis
11/2020 - 04/2005
3Chagas Disease (American Trypanosomiasis)
03/2017 - 01/2012
3Inflammation (Inflammations)
03/2017 - 04/2008
2Neglected Diseases
11/2020 - 01/2014
2Parasitemia
03/2017 - 01/2009
2Asymptomatic Diseases
04/2011 - 10/2010
2Cutaneous Leishmaniasis
10/2010 - 09/2005
1Disease Progression
01/2021
1Coinfection
11/2020
1Dog Diseases (Disease, Canine)
05/2020
1Fibrosis (Cirrhosis)
03/2017
1Anemia
01/2013
1Granuloma
04/2008

Drug/Important Bio-Agent (IBA)

26VaccinesIBA
01/2022 - 06/2004
13AntigensIBA
12/2020 - 04/2005
6Immunoglobulin G (IgG)IBA
01/2020 - 02/2007
6AntibodiesIBA
02/2018 - 04/2005
5Proteins (Proteins, Gene)FDA Link
01/2015 - 02/2007
5SaponinsIBA
12/2013 - 11/2007
4Interleukin-10 (Interleukin 10)IBA
01/2021 - 01/2012
4CytokinesIBA
03/2014 - 02/2009
4Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2013 - 01/2009
3miltefosine (Impavido)IBA
01/2022 - 11/2020
3Pharmaceutical PreparationsIBA
12/2020 - 01/2014
3Biological ProductsIBA
12/2020 - 01/2012
3Peptides (Polypeptides)IBA
10/2019 - 10/2010
2Monoclonal AntibodiesIBA
01/2022 - 01/2021
2Interleukin-10 ReceptorsIBA
01/2022 - 01/2021
2EpitopesIBA
12/2021 - 07/2019
2Recombinant ProteinsIBA
12/2020 - 01/2015
2DNA (Deoxyribonucleic Acid)IBA
10/2018 - 11/2013
2anti-IgGIBA
12/2017 - 10/2010
2ChemokinesIBA
03/2014 - 12/2013
2Peroxidase (Myeloperoxidase)IBA
11/2013 - 10/2010
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
06/2011 - 01/2009
2ImmunosorbentsIBA
05/2007 - 04/2005
2EnzymesIBA
05/2007 - 04/2005
1Meglumine AntimoniateIBA
01/2022
1Liposomes (Liposome)IBA
01/2022
1Combined VaccinesIBA
12/2021
1TamoxifenFDA LinkGeneric
07/2021
1NanocapsulesIBA
07/2021
1Amphotericin B (Amphotericin)FDA LinkGeneric
11/2020
1Immunologic Factors (Immunomodulators)IBA
11/2020
1NucleosidesIBA
07/2019
1triphosphoric acid (triphosphate)IBA
07/2019
1Biomarkers (Surrogate Marker)IBA
07/2019
1decamethrin (deltamethrin)IBA
01/2018
1anti-IgMIBA
12/2017
1Kinetoplast DNA (kDNA)IBA
12/2017
1NifurtimoxIBA
03/2017
1Alanine Transaminase (SGPT)IBA
12/2014
1Messenger RNA (mRNA)IBA
03/2014
1Chemokine CCL5IBA
03/2014
1Interleukin-12 Subunit p40IBA
03/2014
1Chemokine ReceptorsIBA
03/2014
1Interleukin-12 (IL 12)IBA
12/2013
1Apyrase (ATP Diphosphatase)IBA
02/2013
1Immune Sera (Antisera)IBA
02/2013
1Hemoglobins (Hemoglobin)IBA
01/2013
1incomplete Freund's adjuvantIBA
01/2012
1Interleukin-8 (Interleukin 8)IBA
01/2012
1Vaccine AdjuvantsIBA
01/2012
1monophosphoryl lipid AIBA
01/2012
1Transcription Factors (Transcription Factor)IBA
04/2011
1Nitric Oxide Synthase (NO Synthase)IBA
04/2009
1Immunoglobulins (Immunoglobulin)IBA
08/2008
1Inactivated VaccinesIBA
08/2008
1Capsules (Microcapsules)IBA
04/2008
1theasinensin AIBA
09/2005
1fucose-binding lectinIBA
06/2004
1Fluorometholone (FML)FDA Link
06/2004

Therapy/Procedure

4Therapeutics
11/2020 - 01/2012
3Immunotherapy
01/2022 - 06/2004
2Drug Therapy (Chemotherapy)
01/2022 - 01/2014
1Immunomodulation
11/2020
1Microspheres (Microsphere)
10/2019
1Euthanasia (Mercy Killing)
01/2018
1Blood Transfusion (Blood Transfusions)
03/2014